Marlyne Barrett as Dr. Maggie Lockwood
Marlyne Nayokah Barrett is an American actress, born on 1 March 1970 in Brooklyn, New York, United States.
Nick Gehlfuss as Dr. Will Halstea
Nicholas Alan Gehlfuss is an American actor, born on 21 January 1985 in Cleveland, Ohio, United States.
S. Epatha Merkerson as Sharon Goodwin
Sharon Epatha Merkerson is an Ethiopian-American film, stage, and television actress, born on 28 November 1952 in Addis Ababa, Ethiopia.
|Spouse||Toussaint L. Jones (1994 – 2006)|
Oliver Platt as Dr. Daniel Charles
Oliver Platt is a Canadian-born American actor, born on 12 January 1960 in Windsor, Canada.
|Spouse||Mary Camilla Bonsal Campbell|
Brian Tee as Dr. Ethan Choi
Jae-Beom Takata, known professionally as Brian Tee, is an American actor, born on 15 March 1977 in Okinawa, Japan.
Torrey DeVitto as Natalie Manning
Torrey Joël DeVitto is an American actress, musician, philanthropist, producer, born on 8 June 1984 in Huntington, New York, United States.
|Spouse||Paul Wesley (2011 – 2013)|
Yaya DaCosta as April Sexton
Camara DaCosta Johnson, better known as Yaya DaCosta, is an American actress and model, born on 15 November 1982 in New York, New York, United States.